The G49 is the latest entry in Glock's line of cross-up pistols like the G45. The G49 features the longer slide of the G47 models paired with the smaller frame of the G19. The shorter grip length allows for better concealment and comfort for everyday carry while the longer barrel length offers a much longer sight radius for improved accuracy. The G49 uses the Gen5 frame pattern, and features the flat-faced grip along with the ambidextrous slide stop. The MOS version features an optic cut that can accept adapter plates for mounting red dot sights.

This model is chambered in 9x19mm and features an all-black finish. Three 15-round magazines are included along with an MOS adapter plate designed for RMR-style optics.