GLOCK 21 GEN5 for Sale
Browse Glock 21 Gen5 listings from verified sellers across the U.S. on GunsAmerica.
Quick Look
The Glock 21 Gen5 continues the legacy of Glock's .45 ACP pistols, offering modern enhancements for reliability and performance. Engineered with Gen5 updates including the Glock Marksman Barrel and ambidextrous controls, it delivers exceptional accuracy and user-friendly features. A trusted option for .45 ACP fans, the Gen5 is gaining favor among law enforcement and civilian users seeking a large-caliber defensive pistol.
Why It's a Top Choice
- Chambered in .45 ACP for stopping power
- Gen5 features like flared magwell & DLC-coated barrel
- Ambidextrous slide stop lever for left/right-handed use
- No finger grooves for better grip fit
- Compatible with Gen4/Gen5 compatible Glock accessories
Key Variants
Glock 21 Gen5 MOS
Ideal for users wanting an optics-ready .45 ACP for defensive or duty use.
Glock 21 Gen4
Previous generation with interchangeable backstraps and original grip texture setup.
Glock 21 SF
Slim Frame version offering a shorter trigger reach and improved ergonomics.
Competitor Comparison
| Feature | Glock 21 Gen5 | Sig Sauer P320 .45 | Smith & Wesson M&P45 M2.0 |
|---|---|---|---|
| MSRP | $650 | $699 | $629 |
| Capacity | 13+1 | 10+1, 13+1 | 10+1, 13+1 |
| Weight | 29.3 oz | 29.4 oz | 27.0 oz |
| Optics-Ready | MOS option | Yes | Yes |
| Trigger Type | Safe Action | Striker-fired | Striker-fired |
| Notable Pro | Proven Glock reliability | Modular fire control group | Enhanced grip texture |
| Notable Con | Larger grip size | Heavier trigger feel | Longer slide compared to G21 |
Best Use Cases
- Home and personal defense
- Law enforcement and duty carry
- Range training and target shooting
- Large-caliber handgun competitions
- Collectors of Gen5 Glock variants
FAQs
What is the magazine capacity of the Glock 21 Gen5?
It comes standard with a 13-round magazine, chambered in .45 ACP.
Can I mount a red dot on the Glock 21 Gen5?
Yes, the MOS version of the Glock 21 Gen5 supports red dot optics via modular plates.
How does the Glock 21 Gen5 differ from Gen4?
Gen5 adds a flared magwell, Glock Marksman Barrel, and ambidextrous slide stop without finger grooves.
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Glock 20 gen5 MOS Factory Rebuilt
$599.99


